THE SIGNIFICANCE OF LIQUORODYNAMIC DISTURBANCES IN THE PATHOGENESIS OF DISCIRCULATORY ENCEPHALOPATHY
Keywords:
dyscerculatory encephalopathy, anaerobic glycolysis, catabolic, metabolism, cerebrovascular accidentsAbstract
Purpose: The goal is to determine the significance of liquorodynamic disturbances in the pathogenesis of dyscirculatory encephalopathy.Material and methods. The study was conducted on 2.27 (118 men, 199 wives) patients with dyscirculatory encephalopathy. The age of the patients ranged from 30 to 60 years (on average 60+-2.0). Diagnosis of DE was carried out on the basis of clinical neurological studies and data from the following objective research methods: MRI of the brain, MRI angiogram of intra and extracranial arteries; Echo-ES, transcranial Dopplerography (TCD); lumbar puncture with measurement of cerebrospinal fluid pressure and determination of residual oxidation of cerebrospinal fluid (ROCF).RESALT: The results of a clinical neurological study showed that cognitive impairment and various neurological deficits to varying degrees of severity were observed in all patients. In 27 (%) patients out of 37 with the first stage of the disease, MRI of the brain showed a moderate expansion of the subarachnoid space of the convexital surface and cisterns of the base of the brain. Thus, the results of clinical-neurological and the above-mentioned objective research methods show that liquorodynamic disturbances in the brain, to varying degrees of severity, occur in all stages of DE and are one of the main factors leading to the development of hypometabolism in the brain tissue.Conclusion: Liquorodynamic disturbance developed as a result of cicatricial adhesions in the brain and its membranes is the main factor leading to catabolic metabolism.
References
Khakimova S.Z., Mamurova I.N., Samiev A.S. Clinical role of neurobrucellosis among patients with chronic radiculopathy. Academy 2019. 29-228. .(in Russ).
Khakimova S. Z., Khamdamova B. K., Kodirov U. O. Comparative correlation of markers of
inflammatory metamorphism in peripheral blood in dorsopathies of various origins // Uzbek
Journal of Science Reports. – 2022. – T. 2. – No. 2. – pp. 12-18. .(in Russ).
Khamdamova B.K., Khakimova S.Z., Kodirov U.A. Features of the neurovascular state of the
spine in dorsopathies in patients with diabetes mellitus // Journal of Biomedicine and Practice.
– 2022. – vol. 7. – No. 6. .(in Russ)
Samiev A.S., Khakimava S.Z., Soibnazarov O.E. Rehabilitation of patients who have
undergone spinal surgery. Journal of Biomedicine and Practice. 2022, vol. 7, issue 1, pp.139-
.(in Russ).
Samiev A.S., Mavlyanova Z.F. British Medical Journal Volume-3, No. 2 39 Optimization of
rehabilitation measures for lumbar spondylogenic radiculopathies.
Samiev A.S., Mavlyanova Z.F. Comprehensive rehabilitation of patients with lumbar
spondylogenic radiculopathies. SCIENCE AND EDUCATION ISSN 2181-0842 VOLIUME
, ISSU 2. 2023. Pp.453-461. .(in Russ).
Aldabergenova A.B, Biryuchkov MYu. Magnetic resonance imaging in the diagnosis of osteochondrosis of the lumbar spine. Journal of Theoretical and Clinical Medicine. 2000;3:107-108 (in Uzbek)
Drivotinov B.V, Polyakova T.D, Pankova M.D. Physical rehabilitation in neurological manifestations of osteochondrosis of the spine: textbook. allowance. Minsk: BGUFK, 2005 (In Russ.)
Khakimova S.Z, Akhmadeeva L.R. Markers of endothelial dysfunction in distal vessels of patients with chronic pain syndrome in dorsopathies of various origins. Uzbek journal of case reports.2022;l. 2:26-30 (In Russ.)
Khakimova S.Z, Atokhodjaeva D.A. Features of Pain Syndrome of Patients with Brucellosis if Damaged Nervous System. Medico-legal update. 2020;20:3.
Mulleman D, Mammou S, Griffoul I, Watier H, Goupille P. Pathophysiology of disk-related sciatica. I. – Evidence supporting a chemical component. Joint Bone Spine. 2006;73:151–158.
Novoseltsev SV. Pathogenetic mechanisms of the formation of lumbar spondylogenic neurological syndromes in patients with herniated lumbar discs. Manual Therapy 2010;3:77-82 (In Russ.)
Asadullaev M.M. Acute pain syndrome in vertebroneurology and its correction. Scientific and practical journal. Neurology.2005;1(25):5-8 (In Russ.)
Samibaev R, Samiev A, Mamurova I. Clinical and electroneuromyographic diagnosis and rehabilitation of vertebrogenic lumbosacral radiculopathy. Youth and medical science in the XXI century. 2017;179-179 (In Russ.)
Skoromets AA, Skoromets AP, Skoromets TA. Neurological status and its interpretation. Educational guide for doctors. MEDpress-inform, 2013;43 (In Russ.)
Tikhanova EP, Sergeeva IV. Clinical manifestations of neurobrucellosis. Modern problems of science and education. 2013;4 (In Russ.)
Tretyakov AV, Tretyakov VP. Clinical and neuroimaging comparisons of pain syndrome in lumbosacral dorsopathy. Neurological Bulletin. 2010;7(3):55-59 (In Russ.)
Filatova ES., Erdes ShF. Polyneuropathy in rheumatoid arthritis: significance in the pathogenesis of pain syndrome. Russian medical journal. 2017:7;470-473 (In Russ.)
Bektashev R.B., Bektashev O.R., Ergashev M.B. “Neurometabolic therapy in the complex treatment of epilepsy” Medical Journal of Uzbekistan. 2015. No. 2 p. 79-80. (In Russ.)
Vershchagin N.V. “Pathology of the vertebrobasilar system and cerebrovascular accidents.” – M. Medicine. 1980 – 312 p. (In Russ.)
Vershchagin N.V., Morgunov V.A., Gulyevskaya T.S.” Pathology of the brain in atherosclerosis and arterial hypertension.” – M. Medicine., 1997-287p. (In Russ.)
Статья поступила в редакцию 10.05.2024; одобрена после рецензирования 21.06.2024; принята к публикации 29.06.2024.
The article was submitted 10.05.2024; approved after reviewing 21.06.2024; accepted for publication 29.06.2024.
Информация об авторах:
Хакимова Сохиба Зиядуллоевна — д.м.н., заведующая кафедрой неврологии факультета последипломного образования Самаркандского государственного медицинского университета, Самарканд, Узбекистан. 0000-0003-4804-3651 ORCID ID
Хамдамова Бахора Комилжоновна — ассистент кафедры неврологии факультета последипломного образования Самаркандского государственного медицинского университета, Самарканд, Узбекистан. https://orcid.org/0009-0003-5749-6940
Абдуллаева Камола Зафаровна, Самаркандский государственный медицинский университет, факультет последипломного образования, кафедра неврологии, клинический координатор - https://orcid.org/0009-0005-4572-6707 Самарканд, Узбекистан.
Источники финансирования: Работа не имела специального финансирования.
Конфликт интересов: Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи.
Вклад авторов:
Хакимова Сохиба Зиядуллоевна — идеологическая концепция работы, написание текста; редактирование статьи;
Хамдамова Бахора Комилжоновна, Абдуллаева Камола Зафаровна — сбор и анализ источников литературы, написание текста.
Information about the authors:
Khakimova Sokhiba Ziyadullaeva — doctor of medical sciences, head at the department of neurology and neurosurgery of the faculty of postgraduate education of Samarkand state medical university, Samarkand, Uzbekistan. https://orcid.org/0000–0003–4804–3651
Abdullaeva Kamola Zafarovna, Samarkand State Medical University, Faculty of Postgraduate Education, Department of Neurology, Clinical Coordinator - https://orcid.org/0009-0005-4572-6707 Samarkand, Uzbekistan.
Sources of funding: The work did not receive any specific funding.
Conflict of interest: The authors declare no explicit or potential conflicts of interest associated with the publication of this article.
Contribution of the authors:
Khakimova Sokhiba Ziyadullaeva — ideological concept of the work, writing the text; editing the article;
Abdullaeva Kamola Zafarovna — collection and analysis of literature sources, writing the text.
