MECHANISMS OF COMORBIDITY OF PERIODONTITIS AND INFLAMMATORY BOWEL PATHOLOGY (LITERATUREREVIEW)
Keywords:
periodontal tissue diseases, inflammatory bowel diseases, microbial invasion, specific periodontal pathogensAbstract
It has been proven that patients with IBP have an increased risk of developing periodontitis with a combined odds ratio of 3-5. In turn, patients with periodontitis have a higher risk of developing ulcerative colitis than patients without periodontitis. Thus, cohort studies prove the mutually reinforcing effect of periodontitis and IBP. Microorganisms play an important role in the pathogenesis of both pathologies (periodontitis and HCV). Microbial invasion plays an important role in the pathogenesis of both pathologies. The development of periodontitis is associated with the proliferation of periodontal pathogenic bacteria leading to the formation of periodontal pockets, the development of periodontal pathogenic bacteria is associated with the release of toxins and enzymes that contribute to their invasion into the mucous membrane of the gums in the depth of periodontal pockets. The proliferation of periodontal pathogens significantly inhibits the host's immune defense, leading to the progression of inflammation. In the pathogenesis of IBP, in turn, it is important to disrupt the interaction between intestinal microorganisms and the immune system of the mucous membrane of the intestinal wall, which arise under the influence of adverse factors. It has been established that some types of microorganisms of the oral cavity can have a negative effect on the intestines.
References
Abe T, Hajishengallis G. Optimization of the ligature-induced periodontitis model in mice. J Immunol Methods. (2013) 394:49–54. doi: 10.1016/j.jim.2013.05.002
Atarashi K, Suda W, Luo C, Kawaguchi T, Motoo I, Narushima S, et al. Ectopic colonization of oral bacteria in the intestine drives T1 cell induction and inflammation. Science. (2017) 358:359–65. doi: 10.1126/science.aan4526
Ben Lagha A, Haas B, Grenier D. Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum. Sci Rep. (2017) 7:44815. doi: 10.1038/srep44815
Cotti E, Mezzena S, Schirru E, Ottonello O, Mura M, Ideo F, et al. Healing of apical periodontitis in patients with inflammatory bowel diseases and under anti-tumor necrosis factor alpha therapy. J Endod. (2018) 44:1777–82. doi: 10.1016/j.joen.2018.09.004
Cueva C, Silva M, Pinillos I, Bartolomé B, Moreno-Arribas MV. Interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer. Nutrients. (2020) 12:625. doi: 10.3390/nu12030625
de Souza HSP, Fiocchi C, Iliopoulos D. The IYP interactome: an integrated view of aetiology, pathogenesis and therapy. Nat Rev Gastroenterol Hepatol. (2017) 14:739–49. doi: 10.1038/nrgastro.2017.110
Feres M, Teles F, Teles R, Figueiredo LC, Faveri M. The subgingival periodontal microbiota of the aging mouth. Periodontol 2000. (2016) 72:30–53. doi: 10.1111/prd.12136
Figueredo CM, Martins AP, Lira-Junior R, Menegat JB, Carvalho AT, Fischer RG, et al. Activity of inflammatory bowel disease influences the expression of cytokines in gingival tissue. Cytokine. (2017) 95:1–6. doi: 10.1016/j.cyto.2017.01.016
Figuero E, Han YW, Furuichi Y. Periodontal diseases and adverse pregnancy outcomes: mechanisms. Periodontol 2000. (2020) 83:175–88. doi: 10.1111/prd.12295
Frank DN St. Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA. (2007) 104:13780–5. doi: 10.1073/pnas.0706625104
Franzosa EA, Sirota-Madi A, Avila-Pacheco J, Fornelos N, Haiser HJ, Reinker S, et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol. (2019) 4:293–305. doi: 10.1038/s41564-018-0306-4
Indriolo A, Greco S, Ravelli P, Fagiuoli S. What can we learn about biofilm/
Jia L, Han N, Du J, Guo L, Luo Z, Liu Y. Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors. Front Cell Infect Microbiol. (2019) 9:262. doi: 10.3389/fcimb.2019.00262
Jia L, Wu R, Han N, Fu J, Luo Z, Guo L, et al. Porphyromonas gingivalis and Lactobacillus rhamnosus GG regulate the Th17/Treg balance in colitis via TLR4 and TLR2. Clin Transl Immunology. (2020) 9:e1213. doi: 10.1002/cti2.1213
Kato T, Yamazaki K, Nakajima M, Date Y, Kikuchi J, Hase K, et al. Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome. mSphere. (2018) 3:e00460-18. doi: 10.1128/mSphere.00460-18
Kato T, Yamazaki K, Nakajima M, Date Y, Kikuchi J, Hase K, et al. Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome. mSphere. (2018) 3:e00460-18. doi: 10.1128/mSphere.00460-18
Kinane DF, Peterson M, Stathopoulou PG. Environmental and other modifying factors of the periodontal diseases. Periodontol 2000. (2006) 40:107–19. doi: 10.1111/j.1600-0757.2005.00136.x
Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. (2017) 3:17038. doi: 10.1038/nrdp.2017.38
Kitamoto S, Nagao-Kitamoto H, Jiao Y, Gillilland MG, Hayashi A, Imai J, et al. The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis. Cell. (2020) 182:447–62.e14. doi: 10.1016/j.cell.2020.05.048
Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. (2018) 16:745–59. doi: 10.1038/s41579-018-0089-x
Lee S, Lee J, Ha J, Choi Y, Kim S, Lee H, et al. Clinical relevance of infections with zoonotic and human oral species of Campylobacter. J Microbiol. (2016) 54:459–67. doi: 10.1007/s12275-016-6254-x
Lertpimonchai A, Rattanasiri S, Arj-Ong Vallibhakara S, Attia J, Thakkinstian A. The association between oral hygiene and periodontitis: a systematic review and meta-analysis. Int Dent J. (2017) 67:332–43. doi: 10.1111/idj.12317
Liu H, Hong XL, Sun TT, Huang XW, Wang JL, Xiong H. Fusobacterium nucleatum exacerbates colitis by damaging epithelial barriers and inducing aberrant inflammation. J Dig Dis. (2020) 21:385–98. doi: 10.1111/1751-2980.12909
Lleal M, Sarrabayrouse G, Willamil J, Santiago A, Pozuelo M, Manichanh C, et al. Single faecal microbiota transplantation modulates the microbiome and improves clinical manifestations in a rat model of colitis. EBioMedicine. (2019) 48:630–41. doi: 10.1016/j.ebiom.2019.10.002
Lourenço TGB, Heller D, Silva-Boghossian CM, Cotton SL, Paster BJ, Colombo APV. Microbial signature profiles of periodontally healthy and diseased patients. J Clin Periodontol. (2014) 41:1027–36. doi: 10.1111/jcpe.12302
Petersen PE, Ogawa H. The global burden of periodontal disease: towards integration with chronic disease prevention and control. Periodontol 2000. (2012) 60:15–39. doi: 10.1111/j.1600-0757.2011.00425.x
Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. (2010) 464:59–65. doi: 10.1038/nature08821
Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D'Aiuto F, Bouchard P, et al. Periodontitis and cardiovascular diseases: consensus report. J Clin Periodontol. (2020) 47:268–88. doi: 10.1111/jcpe.13189
Sartor RB, Wu GD. Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches. Gastroenterology. (2017) 152:327–339.e4. doi: 10.1053/j.gastro.2016.10.012
Yin W, Ludvigsson JF, Liu Z, Roosaar A, Axéll T, Ye W. Inverse association between poor oral health and inflammatory bowel diseases. Clin Gastroenterol Hepatol. (2017) 15:525–31. doi: 10.1016/j.cgh.2016.06.024
Zhang Y, Zhen M, Zhan Y, Song Y, Zhang Q, Wang J. Population-genomic insights into variation in Prevotella intermedia and Prevotella nigrescens isolates and its association with periodontal disease. Front Cell Infect Microbiol. (2017) 7:409. doi: 10.3389/fcimb.2017.00409
Zhang YZ, Li YY. Inflammatory bowel disease: pathogenesis. World J
