MIYOKIN IRISIN POLIKISTIK TUXUMDON SINDROMINING YANGI BELGISI SIFATIDA
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PTS, irisin, miokin, insulin qarshiligi##article.abstract##
Polikistik tuxumdon sindromi (PTS) - bu tuxumdonlarning multifollikulyar tuzilishi va ayollarda gormonal nomutanosiblik bilan tavsiflangan endokrin kasallik. Irisin jismoniy faoliyatga javoban mushaklar tomonidan ishlab chiqariladigan garmon bo'lib, organizmdagi energiya almashinuvining muhim regulyatori hisoblanadi. Shunga asoslanib, bizning tadqiqotimizning maqsadi PTS bilan kasallangan ayollarda irisin darajasini baholashdir. Materiallar va usullar: PTS bilan kasallangan 24 ayol va nazorat guruhidagi 21 ayol kesma tadqiqotiga kiritilgan.
Natijalar. Tadqiqotda PTS bilan kasallangan 24 ayol va nazorat guruhidagi 21 ayol ishtirok etdi. PTS bilan kasallangan ayollarning 73,9% oligoanovulatsiyaga ega. Шунингдек, PTS bilan kasallangan ayollarning 91,3% ultratovush tekshiruvida PTS belgilariga ega edi. PTS ayollarida insulin darajasi va insulin qarshiligi indeksi nazorat ayollarga qaraganda statistik jihatdan yuqori bo’lib belgilandi (p = 0,02). Miokin irisinga kelsak, u PTS guruhida nazorat guruhiga qaraganda statistik jihatdan yuqori chiqdi (p = 0,03). Bu PTS bilan bog'liq ba'zi metabolik o'zgarishlar yoki anormalliklarning mavjudligini ko'rsatishi mumkin. Xulosa: Erishilgan natijalar ushbu sindromning mexanizmlari va oqibatlarini yaxshiroq tushunish uchun PTS bilan kasallangan ayollarda metabolik parametrlar va tana tarkibini o'rganish muhimligini ko'rsatadi. Irisin va PTS o'rtasidagi munosabatlarni tasdiqlash va yaxshiroq tushunish uchun, shuningdek, uning insulin qarshiligi va boshqa metabolik jarayonlarni tartibga solishdagi rolini tasdiqlash uchun keyingi klinik tadqiqotlar zarur.
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