ОСОБЕННОСТИ ТЕЧЕНИЯ БЕРЕМЕННОСТИ У ЖЕНЩИН С СИНДРОМОМ ПОЛИКИСТОЗНЫХ ЯИЧНИКОВ
Ключевые слова:
Синдром поликистозных яичников, беременность, осложнение, женское здоровье, бесплодиеАннотация
СПКЯ – комплексный синдром репродуктивных, метаболических и психологических проблем, характеризующийся разнообразием клинических проявлений и являющийся основной причиной женского бесплодия. Синдром поликистозных яичников (СПКЯ), гетерогенное состояние, характеризующееся метаболическими изменениями и бесплодием, также тесно связан с материнскими, неонатальными и акушерскими осложнениями.
Библиографические ссылки
Агабабян, Л. Р., and З. Ш. Исраилова. "БЕРЕМЕННОСТЬ У ПАЦИЕНТОК С ГИПЕРАНДРОГЕНИЕЙ." Science and innovation in the education system 2.11 (2023): 21-24;
А.В. Царькова, В.Е. Балан, Ю.П. Титченко Патогенез эндотелиальной дисфункции при синдроме поликистозных яичников. Журнал «Проблемы репродукции» 2021, Т. 27, №6, DOI: 10.17116/repro20212706147.
Беременность при СПКЯ: особенности течения и отдаленные результаты / В. В. Енькова, Е. В. Енькова, Е. В. Киселева, О. В. Хоперская, Е. Я.Сенцова // Научный диалог: вопросы медицины: сборник научных трудов по материалам XXII международной научной конференции. – Санкт-Петербург,2020. – С. 18-22.
Бан, Мяомяо и др. «Связь между синдромом поликистозных яичников у матери, подвергающейся вспомогательным репродуктивным технологиям, и осложнениями беременности и неонатальными исходами: систематический обзор и метаанализ». Журнал исследований яичников 17.1 (2024): 6.
Кулакова, С. А., and А. И. Гомон. "Прогноз беременности и перинатальных исходов при наличии синдрома поликистозных яичников." Медицинский алфавит 19 (2023): 39-43.
Михайлова, Нина Дмитриевна, et al. "Особенности программ вспомогательных репродуктивных технологий у женщин позднего репродуктивного возраста с синдромом поликистозных яичников." Obstetrics and Gynecology 9 (2022): 87-93.
Николаенков, Игорь Павлович, et al. "Особенности течения беременности у пациенток с синдромом поликистозных яичников." Журнал акушерства и женских болезней 69.5 (2020): 105-112.
Abruzzese, Giselle A., et al. "Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development." WIREs mechanisms of disease 14.5 (2022): e1558;
Alenezi SA, Khan R, Amer S. The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF-A Systematic Review and Meta-Analysis. J Clin Med. 2024 Mar 10;13(6):1578. doi: 10.3390/jcm13061578. PMID: 38541804; PMCID: PMC10970739.
Aune D, Saugstad OD, Henriksen T, Tonstad S. Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis. JAMA. 2014;311:1536–46.
Braakhekke M, Kamphuis EI, van Rumste MM, Mol F, van der Veen F, Mol BW. How are neonatal and maternal outcomes reported in randomised controlled trials (RCTs) in reproductive medicine? Hum Reprod. 2014;29:1211–7.
Barnhart KT. Assisted reproductive technologies and perinatal morbidity: interrogating the association. Fertil Steril. 2013;99:299–302;
Bahri Khomami M, Teede HJ, Joham AE, Moran LJ, Piltonen TT, Boyle JA. Clinical management of pregnancy in women with polycystic ovary syndrome: An expert opinion. Clin Endocrinol (Oxf). 2022 Aug;97(2):227-236. doi: 10.1111/cen.14723. Epub 2022 Apr 5. PMID: 35383999; PMCID: PMC9544149.
Boomsma CM, Eijkemans MJ, Hughes EG, Visser GH, Fauser BC, Macklon NS. A metaanalysis of pregnancy outcomes in women with polycystic ovary syndrome. Hum Reprod Update. 2016;12:673–83.;
Bahri Khomami M, Shorakae S, Hashemi S, Harrison CL, Piltonen TT, Romualdi D, Tay CT, Teede HJ, Vanky E, Mousa A. Systematic review and meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Nat Commun. 2024 Jul 4;15(1):5591. doi: 10.1038/s41467-024-49749-1. PMID: 38965226; PMCID: PMC11224312.
Bisson M, Sériès F, Giguère Y, Pamidi S, Kimoff J, Weisnagel SJ, Marc I. Gestational diabetes mellitus and sleep-disordered breathing. Obstet Gynecol. 2014;123:634–41.
Brosens I, Benagiano G. Menstrual preconditioning for the prevention of major obstetrical syndromes in polycystic ovary syndrome. Am J Obstet Gynecol. 2015;213:488–93.
Cai GJ, Sun XX, Zhang L, Hong Q. Association between maternal body mass index and congenital heart defects in offspring: a systematic review. Am J Obstet Gynecol. 2014;211:91–117.
D'Alterio, Maurizio N., et al. "Pregnancy outcomes in women with polycystic ovarian syndrome." Minerva Obstetrics and Gynecology 74.1 (2021): 45-59.
Doherty DA, Newnham JP, Bower C, Hart R. Implications of polycystic ovary syndrome for pregnancy and for the health of offspring. Obstet Gynecol. 2015;125:1397–406.
DoPierala AL, Bhatta S, Raja EA, Bhattacharya S, Bhattacharya S. Obstetric consequences of subfertility: a retrospective cohort study. BJOG. 2015;3:1–9.
Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, NICHD Reproductive Medicine Network, et al. Letrozole, gonadotropin, or clomiphene for unexplained infertility. N Engl J Med. 2015;373:1230–40.
Declercq E, MacDorman M, Cabral H, Stotland N. Prepregnancy body mass index and infant mortality in 38 U.S. States, 2012–2013. Obstet Gynecol. 2016;127:279–87;
de Wilde MA, Veltman-Verhulst SM, Goverde AJ, Lambalk CB, Laven JS, Franx A, Koster MP, Eijkemans MJ, Fauser BC. Preconception predictors of gestational diabetes: a multicentre prospective cohort study on the predominant complication of pregnancy in polycystic ovary syndrome. Hum Reprod. 2014;29:1327–36. ;
Ensing S, Abu-Hanna A, Roseboom TJ, Repping S, van der Veen F, Mol BW, Ravelli AC. Risk of poor neonatal outcome at term after medically assisted reproduction: a propensity scorematched study. Fertil Steril. 2015;104.
Guo X, Yao Y, Wang T, Wu J, Jiang R. The impact of hyperandrogenemia on pregnancy complications and outcomes in patients with PCOS: a systematic review and meta-analysis. Hypertens Pregnancy. 2024 Dec;43(1):2379389. doi: 10.1080/10641955.2024.2379389. Epub 2024 Jul 14. PMID: 39004840.
Han AR, Kim HO, Cha SW, Park CW, Kim JY, Yang KM, Song IO, Koong MK, Kang IS. Adverse pregnancy outcomes with assisted reproductive technology in non-obese women with polycystic ovary syndrome: a case-control study. Clin Exp Reprod Med. 2011;38:103–8.
Joham AE, Palomba S, Hart R. Polycystic ovary syndrome, obesity, and pregnancy. Semin Reprod Med. 2016;34:93–101.
Joham AE, Ranasinha S, Zoungas S, Moran L, Teede HJ. Gestational diabetes and type 2 diabetes in reproductive-aged women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2014;99:447–52.
Kollmann M, Klaritsch P, Martins WP, Guenther F, Schneider V, Herzog SA, Craciunas L, Lang U, Obermayer-Pietsch B, Lerchbaum E, Raine-Fenning N. Maternal and neonatal outcomes in pregnant women with PCOS: comparison of different diagnostic definitions. Hum Reprod. 2015;30:2396–403.
Kjerulff LE, Sanchez-Ramos L, Duffy D. Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis. Am J Obstet Gynecol. 2011;204:558.e1–6.;
Koster MP, de Wilde MA, Veltman-Verhulst SM, Houben ML, Nikkels PG, van Rijn BB, Fauser BC. Placental characteristics in women with polycystic ovary syndrome. Hum Reprod. 2015;30:2829–37.
Løvvik TS, Wikström AK, Neovius M, Stephansson O, Roos N, Vanky E, Magnussen EB, Vatten LJ. Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population-based cohort study. BJOG. 2016;122:1295–302.
Lynch AM, Hart JE, Agwu OC, Fisher BM, West NA, Gibbs RS. Association of extremes of prepregnancy BMI with the clinical presentations of preterm birth. Am J Obstet Gynecol. 2014;210:428–32.
Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Huang H, Yan Q, Alvero R, NICHD Reproductive Medicine Network, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014; 371:119–29.
Markin, L. B., et al. "Association of polycystic ovary syndrome with multiple health factors and adverse pregnancy outcomes." International journal of endocrinology (Ukraine) 19.2 (2023): 137-142;
Makieva S, Saunders PTK, Norman JE. Androgens in pregnancy: roles in parturition. Hum Reprod Update. 2014;20:542–59.
Maliqueo M, Lara HE, Sánchez F, Echiburú B, Crisosto N, Sir-Petermann T. Placental steroidogenesis in pregnant women with plycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2013;166:151–5.
Mutsaerts MA, van Oers AM, Groen H, Burggraaff JM, Kuchenbecker WK, Perquin DA, et al. Randomized trial of a lifestyle program in obese infertile women. N Engl J Med. 2016;374:1942–53.
Messerlian C, Platt RW, Tan S-L, Gagnon R, Basso O. Low-technology assisted reproduction and the risk of preterm birth in a hospital-based cohort. Fertil Steril. 2015;103:81–8.
Malchau SS, Loft A, Henningsen AK, Nyboe Andersen A, Pinborg A. Perinatal outcomes in 6,338 singletons born after intrauterine insemination in Denmark, 2007 to 2012: the influence of ovarian stimulation. Fertil Steril. 2014;102:1110–6.
Moran LJ, Norman RJ, Teede HJ. Metabolic risk in PCOS: phenotype and adiposity impact. Trends Endocrinol Metab. 2015;26:136–43
Maliqueo M, Sundstrom-Poromaa I, Vanky E, Fornes R, Benrick A, Akerud H, Stridsklev S, Labrie F, Jansson T, Stener-Victorin E. Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Hum Reprod. 2015;30:692–700.
Naver KV, Grinsted J, Larsen SO, Hedley PL, Jørgensen FS, Christiansen M, Nilas L. Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. BJOG. 2014;121:575–81.
Nassif DS, Januário BL, Sousa BA, Thabane L, Abbade JF. Effectiveness of metformin to pregnant women with PCOS to reduce spontaneous abortion and gestational diabetes mellitus: a protocol for an overview of reviews. BMJ Open. 2024 Mar 25;14(3):e078217. doi: 10.1136/bmjopen-2023-078217. PMID: 38531582; PMCID: PMC10966794.
Nahuis MJ, Oude Lohuis EJ, Bayram N, Hompes PG, Oosterhuis GJ, van der Veen F, et al. Pregnancy complications and metabolic disease in women with clomiphene citrate-resistant anovulation randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotropins: a 10-year follow-up. Fertil Steril. 2014;101:270–4.
Palomba S, de Wilde MA, Falbo A, Koster MP, La Sala GB, Fauser BC. Pregnancy complications in women with polycystic ovary syndrome. Hum Reprod Update. 2015;21:575–92. ;
Palomba S, Santagni S, Gibbins K, La Sala GB, Silver RM. Pregnancy complications in spontaneous and assisted conceptions of women with infertility and factors of subfertility. A comprehensive review. Reprod Biomed Online. 2016;33:612–28.;
Palomba S, Chiossi G, Falbo A, Orio F, Tolino A, Colao A, La Sala GB, Zullo F. Low-grade chronic inflammation in pregnant women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2014;99:2942–51. ;
Palomba S, Falbo A, Chiossi G, Muscogiuri G, Orio F, Tolino A, Colao A, La Sala GB, Zullo F. Lipid profile in pregnant women with polycystic ovary syndrome. Steroids. 2014;88C:36–43.
Pan ML, Chen LR, Tsao HM, Chen KH. Relationship between polycystic ovarian syndrome and subsequent gestational diabetes mellitus: a nationwide population-based study. PLoS One. 2015;10:e0140544.
Palomba S, de Wilde MA, Falbo A, Koster MP, La Sala GB, Fauser BC. Pregnancy complications in women with polycystic ovary syndrome. Hum Reprod Upd.
Palomba S, Falbo A, Russo T, Tolino A, Orio F, Zullo F. Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes. Fertil Steril. 2020;94:1805–11.
Palomba S, La Sala GB. Pregnancy complications in women with polycystic ovary syndrome: importance of diagnostic criteria or of phenotypic features? Hum Reprod. 2016;31:223–4.
Palomba S, Falbo A, Chiossi G, Tolino A, Tucci L, La Sala GB, Zullo F. Early trophoblast invasion and placentation in women with different polycystic ovary syndrome phenotypes. Reprod Biomed Online. 2014;29:370–81.
Pattnaik L, Naaz SA, Das B, Dash P, Pattanaik M. Adverse Pregnancy Outcome in Polycystic Ovarian Syndrome: A Comparative Study. Cureus. 2022 Jun 9;14(6):e25790. doi: 10.7759/cureus.25790. PMID: 35836460; PMCID: PMC9273198;
Pandey S, Shetty A, Hamilton M, Bhattacharya S, Maheshwari A. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and metaanalysis. Hum Reprod Update. 2012;18:485–50;
Palomba S, Russo T, Falbo A, Di Cello A, Amendola G, Mazza R, Tolino A, Zullo F, Tucci L, La Sala GB. Decidual endovascular trophoblast invasion in women with polycystic ovary syndrome: an experimental case-control study. J Clin Endocrinol Metab. 2012;97:2441–9.
Parker, Jim, et al. "Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies." Journal of Clinical Medicine 13.6 (2024): 1774.
Palomba S, La Sala GB. Menstrual preconditioning for the prevention of pregnancy complications in women with polycystic ovary syndrome (PCOS): clinical opinion or viewpoint-this is the question. Am J Obstet Gynecol. 2016;214:417–8.
Qin JZ, Pang LH, Li MJ, Fan XJ, Huang RD, Chen HY. Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2013;11:56.
Rees DA, Jenkins-Jones S, Morgan CL. Contemporary reproductive outcomes for patients with polycystic ovary syndrome: a retrospective observational study. J Clin Endocrinol Metab. 2016;101:1664–72.
Roos N, Kieler H, Sahlin L, Ekman-Ordeberg G, Falconer H, Stephansson O. Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study. BMJ. 2011;343:d6309.
Silver R. Infertility trial outcomes: healthy moms and babies. Fertil Steril. 2014;101: 1209–16; Barnhart KT. Live birth is the correct outcome for clinical trials evaluating therapy for the infertile couple. Fertil Steril. 2014;101:1205–8.
Sunderam S, Kissin DM, Crawford SB, Folger SG, Jamieson DJ, Warner L, et al. Assisted reproductive technology surveillance – United States, 2013. MMWR Surveill Summ. 2015;64:1–25.
Society of Obstetricians and Gynaecologists of Canada. Pregnancy outcomes after assisted human reproduction. J Obstet Gynaecol Can. 2014;36:64–83.
Sir-Petermann T, Maliqueo M, Angel B, Lara HE, Pérez-Bravo F, Recabarren SE. Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization. Hum Reprod. 2012;17:2573–9.
Stanford JB, Simonsen SE, Baksh L. Fertility treatments and adverse perinatal outcomes in a population-based sampling of births in Florida, Maryland, and Utah: a cross-sectional study. BJOG. 2016;123:718–29.
Sterling L, Liu J, Okun N, Sakhuja A, Sierra S, Greenblatt E. Pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization. Fertil Steril. 2016;105: 791–7.
Sentilhes L, Sénat MV, Boulogne AI, Deneux-Tharaux C, Fuchs F, Legendre G, et al. Shoulder dystocia: guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2016;203:156–61.
Thien, Tan Chau. "Pregnancy and Early Life Complications of PCOS." Fertility & Reproduction 5.04 (2023): 191-191.
Tang WZ, Liu TH, Lan X. Assessing the Impact of PCOS on Pregnancy Complications in FET Cycles: Unexplored Factors and Clinical Implications. Fertil Steril. 2024 Aug 6:S0015-0282(24)01936-8. doi: 10.1016/j.fertnstert.2024.08.313. Epub ahead of print. PMID: 39117171;
Tariq, Laiba, et al. "Association of Pregnancy Outcome Complications Among Females with Polycystic Ovary Syndrome: Complications Among Females with Polycystic Ovary Syndrome." DIET FACTOR (Journal of Nutritional and Food Sciences) (2022): 12-16.
Tobias DK, Chavarro JE, Williams MA, Buck Louis GM, Hu FB, Rich-Edwards J, Missmer SA, Zhang C. History of infertility and risk of gestational diabetes mellitus: a prospective analysis of 40,773 pregnancies. Am J Epidemiol. 2013;178:1219–25.
Vegad, Surabhi. "Comparative Analysis of antenatal and fetal complications in pregnant women with and without history of polycystic ovary syndrome." (2022): 1845-1853.
Waseem, Nazeeha. "Pregnancy in a Secondary Infertile Woman with Polycystic Ovarian Syndrome (PCOS)–A Case Report." Sch J Med Case Rep 1 (2021): 70-73;
Wartena, Rosa, and Mushi Matjila. "Polycystic ovary syndrome and recurrent pregnancy loss, a review of literature." Frontiers in Endocrinology 14 (2023): 1183060;
Wang Q, Luo L, Lei Q, Lin MM, Huang X, Chen MH, Zeng YH, Zhou CQ. Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome. Reprod Biomed Online. 2016;33:85–92. pii: S1472-6483(16)30069-4.
Yu, Ting, et al. "Association between menstrual patterns and adverse pregnancy outcomes in patients with polycystic ovary syndrome." Frontiers in Endocrinology 12 (2021): 740377;
Yang J, Chen C. Hormonal changes in PCOS. J Endocrinol. 2024 Feb 15;261(1):e230342. doi: 10.1530/JOE-23-0342. PMID: 38285626;
