CLINICAL FEATURES OF CHRONIC MIGRAINE AND THEIR IMPACT ON COGNITIVE FUNCTIONS
Keywords:
chronic migraine, cognitive impairment, attention, memory, executive functions, neuroinflammation, quality of life, CGRPAbstract
This literature review examines the clinical features of chronic migraine (CM) and its impact on cognitive functions based on publications from 2020–2025 retrieved from Google Scholar and Scopus. The search followed PRISMA guidelines; 20 articles were included in the analysis. Findings indicate significant impairments in attention, memory, executive functions, and information processing speed in patients with CM, persisting during the interictal period. Comorbid depression, anxiety, and sleep disorders further aggravate cognitive deficits.
References
Steiner T.J., Stovner L.J. Global epidemiology of migraine and its implications for public health and health policy. Nat Rev Neurol. 2023; 19(2): 109–117. https://doi.org/10.1038/s41582-022-00763-1
Safiri S. et al. Global, regional, and national burden of migraine in 204 countries and territories, 1990 to 2019. Pain. 2022; 163(3): e293–e309. https://doi.org/10.1097/j.pain.0000000000002275
Ashina M. et al. Migraine. Nat Rev Dis Primers. 2022; 8: 2. https://doi.org/10.1038/s41572-021-00328-4
Fernandes C. et al. Migraine and cognitive dysfunction: a narrative review. J Headache Pain. 2024; 25(1): 221. https://doi.org/10.1186/s10194-024-01923-y
Pizer J.H. et al. Neuropsychological function in migraine headaches: an expanded comprehensive multidomain meta-analysis. Neurology. 2024; 102(4): e208109. https://doi.org/10.1212/WNL.0000000000208109
Cuciureanu D.I. et al. Migraine Comorbidities. Life. 2024; 14(1): 74. https://doi.org/10.3390/life14010074
Rattanawong W., Rapoport A., Srikiatkhachorn A. Neurobiology of migraine progression. Neurobiol Pain. 2022; 12: 100094. https://doi.org/10.1016/j.ynpai.2022.100094
Omaer A. et al. Improvement of comorbid anxiety and depression in patients with migraine treated with injectable preventive CGRP antagonists. Saudi Pharm J. 2024; 32: 101989. https://doi.org/10.1016/j.jsps.2024.101989
Fernandes C., Gil-Gouveia R. Deciphering the mechanisms: Pathophysiology of migraine-related cognitive dysfunction. Cephalalgia. 2025; 45(4). https://doi.org/10.1177/03331024251368328
Cankaya S. et al. Hippocampal connectivity dynamics and volumetric alterations predict cognitive status in migraine: A resting-state fMRI study. NeuroImage. 2025; 305: 120961. https://doi.org/10.1016/j.neuroimage.2024.120961
Gu L., Wang Y., Shu H. Association between migraine and cognitive impairment. J Headache Pain. 2022; 23(1): 89. https://doi.org/10.1186/s10194-022-01462-4
López-Medina D.C. et al. Cognition, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period. BMC Neurol. 2025; 25(1): 108. https://doi.org/10.1186/s12883-025-04122-7
Qin T., Chen C. Cognitive dysfunction in migraineurs. Medicina. 2022; 58(7): 870. https://doi.org/10.3390/medicina58070870
Choudhary A.K. Chronic Migraine and Accelerated Brain Ageing: A Focus on Hippocampal Atrophy, Neuroimaging, and Cognitive Decline. Med Res Archives. 2025; 13(7). https://doi.org/10.18103/mra.v13i7.6728
Coppola G. et al. Pathophysiological bases of comorbidity in migraine. Front Hum Neurosci. 2021; 15: 640574. https://doi.org/10.3389/fnhum.2021.640574
Chen Y.M. et al. Clinical and psychological predictors of sleep quality in chronic migraine. BMC Neurol. 2025; 25: 156. https://doi.org/10.1186/s12883-025-04156-x
Vila-Pueyo M. et al. Advances in understanding migraine pathophysiology: a bench to bedside review. Front Mol Neurosci. 2024; 17: 1355281. https://doi.org/10.3389/fnmol.2024.1355281
Anastasiadou S. et al. Effects of Fremanezumab on psychiatric comorbidities in difficult-to-treat patients with chronic migraine. J Clin Med. 2023; 12(13): 4313. https://doi.org/10.3390/jcm12134313
Wang Y. et al. P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine. J Headache Pain. 2022; 23(1): 75. https://doi.org/10.1186/s10194-022-01443-7
Chen Y.J. et al. Cognitive reserve and its associations with pain, anxiety, and depression in patients with chronic migraine. J Clin Med. 2025; 14(15): 5193. https://doi.org/10.3390/jcm14155193