THE LEVEL OF B VITAMINS AND VITAMIN D IN PATIENTS WITH CHRONIC KIDNEY DISEASE, DEPENDING ON THE PROGRESSION OF THE DISEASE

Authors

  • Daminov B.T
  • Ortiqboyev J.O.

Keywords:

chronic kidney disease, vitamin status, hypovitaminosis, pathogenetic role

Abstract

In order to study the correlation between the levels of vitamin B6, folic acid (vitamin B9) and vitamin D with the clinical course of CKD, 153 patients aged 20 to 94 years were examined, with an average age of 57.9±2.3 years. The analysis of the obtained data showed that the average concentration of vitamin B6 and folic acid in all cases was within the lower limit of the standard values. In all cases, a decrease in vitamin D was found, corresponding to both deficiency and deficiency. Correlation analysis proved the average dependence of vitamin D on GFR.

References

Батюшин М.М. Хроническая болезнь почек: современное состояние проблемы // Рациональная фармакотерапия в кардиологии. — 2020. — № 8. — С. 938–947.

Зверев ЯФ, Брюханов ВМ. Современные представ ления о механихмах почечного действия альдостерона // Нефрология. - 2021; 4(5): 916

Смирнов А.В., Есаян А.М., Каюков И.Г. и др. Современные подходы к замедлению прогрессирования болезни почек. // Нефрология. — 2023. — Т8. — №3. — С.89-99

Томилина Н.А., Бикбов Б.Т. Эпидемиология хронической почечной недостаточности и новые подходы к классификации и оценке тяжести хронических прогрессирующих заболе-ваний почек // Терапевтический архив. — 2015. — № 6.

Шайхова Г. И., Отажонов И. А., Рустамова М. Т. Малобелковая диета для больных с хронической почечной недостаточностью // Экспериментальная и клиническая гастроэнтерология. — 2019. — № 12. — С. 135–142.

Chien S.C., Li S.Y., ChenY.T. et al. Folic acid supplementation in end-stage renal disease patients reduces total mortality rate. J. Nephrol. 2023; 26 (6): 1097–1104. DOI: 10.5301/jn.5000276.

Dangour A.D., Allen E., Clarke R. et al. Effects of vitamin B-12 supplementation on neurologic and cognitive function in older people: a randomized controlled trial. Am. J. Clin. Nutr. 2015; 102 (3): 639–647. DOI: 10.3945/ajcn.115.110775.

Filipov JJ, Zlatkov BK, Dimitrov EP, Svinarov D. Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients.// Biotechnol Biotechnol Equip. 2015;29(2):331–5.

Franques J., Chiche L., Mathis S. Sensory neuronopathy revealing severe vitamin B12 deficiency in a patient with anorexia nervosa: An often-forgotten reversible cause. Nutrients. 2017; 9 (3): 281. DOI: 10.3390/nu9030281.

Jankowska M., Rutkowski B., Debska-Slizien A. Vitamins and microelement bioavailability in different stages of chronic kidney disease. Nutrients. 2017; 9 (3): 282. DOI: 10.3390/nu9030282.

Levey AS, de Jong PE, Coresh J, El Nahas M, Astor BC, Matsushita K, et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int. 2011;80(1):17–28.

Levin A, Stevens PE. Summary of KDIGO 2012 CKD Guideline: behind the scenes, need for guidance, and a framework for moving forward. Kidney Int. 2014;85(1):49–61.

Maladkar M., Tekchandani C., Dave U. Post-marketing surveillance of fixed dose combination of methylcobalamine, alpha lipoic acid, folic acid, biotin, benfotiamine & vitamin B6 –nutripathy for the management of peripheral neuropathy. J. Diabetes Mellitus. 2018; 4: 124–132. DOI: 10.4236/jdm.2014.42019.

Martín-del-Campo F., Batis-Ruvalcaba C., GonzálezEspinoza L. et al. Dietary micronutrient intake in peritoneal dialysis patients: relationship with nutrition and inflammation status. Perit. Dial. Int. 2022; 32 (2): 183–191. DOI: 10.3747/pdi.2010.00245.

Mehrotra R, Kermah DA, Salusky IB, Wolf MS, Thadhani RI, Chiu YW, et al. Chronic kidney disease, hypovitaminosis D, and mortality in the United //States. Kidney Int. 2019;76(9):977–83.

Pilz S, Iodice S, Zittermann A, Grant WB, Gandini S. Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies // Am J Kidney Dis. 2021;58(3):374–82.

Soohoo M., Feng M., Obi Y. et al. Changes in markers of mineral and bone disorders and mortality in incident hemodialysis patients. Am. J. Nephrol. 2016; 43 (2): 85–96. DOI: 10.1159/000444890.

Webster AC, Nagler EV, Morton RL, Masson P. Chronic Kidney Disease //Lancet. 2017;389(10075):1238–52.

Published

2025-10-30