INTERRELATIONSHIP BETWEEN GASTROESOPHAGEAL REFLUX DISEASE AND RESPIRATORY DISEASES: GENERAL PATHOGENETIC MECHANISMS AND MODERN RESEARCH FINDINGS
Keywords:
Gastroesophageal reflux disease (GERD), Chronic obstructive pulmonary disease (COPD), Bronchial asthma, Comorbidity, Pathogenesis, Microaspiration, Systemic inflammation, Proton pump inhibitors (PPIs)Abstract
The article explores the relationship between gastroesophageal reflux disease (GERD) and respiratory conditions such as chronic obstructive pulmonary disease (COPD), bronchial asthma, and idiopathic pulmonary fibrosis (IPF). It examines shared pathogenic mechanisms, including microaspiration of gastric contents, vagus nerve stimulation, and systemic inflammation. The study highlights the impact of GERD on the exacerbation of respiratory symptoms, increased hospitalization rates, and worsening of overall prognosis.
References
Harding, S.M., & Richter, J.E. (2021). The role of reflux in asthma and chronic obstructive pulmonary disease. Chest, 159(2), 654-665.
Shirai, T., Mikamo, M., & Tsuchiya, T. (2014). Real-world effect of gastroesophageal reflux disease on cough-related quality of life and disease status in asthma and COPD. Journal of Asthma, 51(12), 1261-1268.
Martinez, F.J., & Vercelli, D. (2022). Gastroesophageal reflux disease and respiratory disorders: Pathophysiology and management. The New England Journal of Medicine, 384(5), 532-540.
He, Y., Chen, S., & Wu, J. (2022). The relationship between GERD and respiratory diseases: A meta-analysis. Journal of Clinical Gastroenterology, 56(1), 24-33.
McGarvey, L.P., Heaney, L.G., & MacMahon, J. (2021). The impact of non-acid reflux on asthma control: A prospective cohort study. European Respiratory Journal, 58(3), 2101-2108.
Howard, L.S., Briggs, D.D. (2021). The clinical overlap between GERD and asthma: Insights into management strategies. Thorax, 76(9), 749-756.
Smith, B.R., Edwards, J.J. (2021). The role of impedance-pH monitoring in managing asthma exacerbations associated with GERD. American Journal of Respiratory and Critical Care Medicine, 204(6), 711-720.
Zou, Y., Chen, Y., & Liu, Q. (2021). Impedance-pH monitoring in the diagnosis of non-erosive GERD in patients with asthma. BMC Pulmonary Medicine, 21(6), 128-135.
Пивоварова, И.В., Жабрев, Д.А., & Петухова, Н.С. (2020). Диагностика гастроэзофагеальной рефлюксной болезни у пациентов с бронхиальной астмой. Вестник современной клинической медицины, 13(4), 30-35.
Алексеев, И.В., Николаева, Е.А. (2021). Применение манометрии высокого разрешения при диагностике ГЭРБ у больных с бронхиальной астмой. Российский медицинский журнал, 29(7), 55-61.
