MORPHOLOGICAL CHARACTERISTICS OF CHANGES IN EXPERIMENTAL DESTRUCTIVE PNEUMONIA DURING ANTIBIOTIC THERAPY
Keywords:
children, destructive pneumonia, white mongrel laboratory ratsAbstract
The article presents data on destructive pneumonia of the lungs, which is often considered as a complication of pneumonia in children, and experimental modeling of this pathology in laboratory outbred rats, its results and morphological characteristics in dynamics. Studying the clinical and radiological parameters of destructive pulmonary pneumonia in children is important for the successful treatment of this disease and improving the quality of life of patients. There is sufficient data in the scientific literature on the clinical parameters of bacterial destructive pneumonia of the lungs. However, in case of pulmonary bacterial destructive pneumonia, there is insufficient data on the pathological, pathomorphological processes occurring in the lungs and pleura, without these data it will be impossible to extrapolate the results of experimental modeling to humans and scientific research in this direction will be required.
References
Вечеркин Владимир Александрович, Тома Дмитрий Александрович, Птицын Владимир Александрович, & Коряшкин Павел Владимирович. Деструктивные пневмонии у детей. Российский вестник детской хирургии, анестезиологии и реаниматологии, 2019-9 (4), 108-115.
Ленева И.А., Леонова Е.И., Махмудова Н.Р., Фалынскова Ирина Николаевна, Федякина И.Т., Зверев В.В., & Михайлова Н.А. (2015). Разработка экспериментальной модели сочетанной вирусно-бактериальной пневмонии. Вопросы вирусологии, 60 (5), 27-31.
Мехриддинов М.К. Дренажное лечение острой бактериальной деструктивной пневмонии у детей. Scientific journal of applied and medical sciences, 2023-2(11), 267–272.
Толстова Е.М., Беседина М.В., Елькина М.А. и др., Этиология и клиническая характеристика деструктивных пневмоний у детей // Инфекционные болезни: новости, мнения, обучение. 2024. Т. 13, № 1. С. 42-51.
Хайбунасова Л.Р., Боровкова К.Е., Салмова Ю.В. Бактериальные инфекции легких. Модели на животных. Лабораторные животные для научных исследований. 2020; 2.
Bosch A. A., Biesbroek G., Trzcinski K., Sanders E. A., Bogaert D. Viral and bacterial interactions in the upper respiratory tract. PLoS Pathog. 2013; 9: e1003057. DOI: 10.1371/journal.ppat.1003057
Barskaya M.A., Terekhina M.I., Munin A.G. Vestnik RGMU. - VestnikRGMU. 2018;4:117. . (in Russ).
Madiyeva M.R., Smagulova D.M., & Baibolova A.A. X-ray diagnosis of acute destructive pneumonia in a 1.5 year old child. Case report. Наука и здравоохранение, 2022-24 (1), 215-219.
Raupov, F.S. Morphological Aspects of the Colon of Human and White Laboratory Rats // Central Asian Journal of Medical and Natural Science.Т.3. №2. С.243-247.
Raupov, F.S., Shavkatov, Sh. Kh. Empirical antibacterial therapy for acute bacterial destructive pneumonia in children. // International Journal of Medical Sciences And Clinical Research. Т.3. №5. Стр.84-89.
Raupov F. S. Acute Bacterial Destructive Pneumonia of the Lungs in Children. Research Journal of Trauma and Disability Studies, 2024-3(5), 506–512.
Raupov F.Sa, & Rashidova M.A. Acute Bacterial Destructive Pneumonia in Children. Research Journal of Trauma and Disability Studies, 2023-2(6), 16–20.
Sly P. D., Zar H. J. The spectrum of lower respiratory tract illness in children after pneumococcal conjugate vaccination. Am. J. Respir. Crit. Care. Med. 2017;195:13-5.
Hraiech S, Papazian L, Rolain JM, Bregeon F. Animal models of polymicrobial pneumonia. Drug Des Devel Ther. 2015 Jun 26;9:3279-92.
Son M, Jo S, Lee JS, Lee DH. Association between oral health and incidence of pneumonia: a population-based cohort study from Korea. Sci Rep. 2020 Jun 12;10(1):9576.