EFFLUX OF IRON PREPARATIONS IN PATIENTS WITH DIFFERENT C3435T MDR1 GENOTYPES
Keywords:
iron deficiency anemia, iron preparations, glycoprotein-P, MDR1 geneAbstract
Temir tanqisligi anemiyasini davolashda C3435T MDR1 gen polimorfizmining temir preparatlari oqimiga ta'sirini baholash. Xuddi shu vaqt davomida temir preparati Fe III (Maltofer) ni bir xil dozada olgan 24 bemorda glikoprotein-P ni kodlaydigan MDR1 genining polimorfizmi bo'yicha tadqiqot o'tkazildi. Ferroterapiyaning samaradorligi davolashdan oldin va keyin o'rganilgan "qizil qon", metabolizm va tanadagi temir zahiralari holatini tavsiflovchi ko'rsatkichlar dinamikasini tahlil qilish asosida baholandi. MDR1 genining C3435T polimorf markeriga ko'ra TT genotipi bo'lgan bemorlarda pankreatik oqimning eng past darajasi aniqlanadi va hujayralar tomonidan temirning maksimal o'zlashtirilishi ta'minlanadi.
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