COVID-19 ИНДУЦИРЛАГАН ЎТКИР ИШЕМИК ИНСУЛТ РИВОЖЛАНИШИДА VEGF ВА IL-6 ПОЛИМОРФИЗМЛАРИНИ АХАМИЯТИ
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IL-6 rs1800795, VEGF rs2010963, цитокинли бўрон, гиперкоагулопатия, ишемик инсулт.##article.abstract##
SARS-CoV-2 вируси билан касалланганлар орасидан, касалликнинг ўткир даврида ишемик инсулт кўплаб беморларда содир бўлмоқда. Бунинг асосий индуцирловчи омили, COVID-19 патогенезида цитокинларни гиперпродуксияси ва коагукяция жараёнини балансини бузилиши – гиперкоагуляция пайдо қилиши орқали бош мия қон томирларида гипертромбоз, артериал эмболизatsiя ва гипоперфузия келтириб чиқариши натижасида қон айланишининг ўткир бузилишига сабаб бўлиб ишемик инсулт асоратини пайдо қилмоқда. Гарчи, SARS-CoV-2 билан инфицирланган беморларда ишемик инсулт келиб чиқиши механизми аниқ ўрганилмаган бўлса-да, бизнинг илмий ишдан кўзланган мақсад бу ҳолат ривожланишида про-яллиғлантирувчи цитокин – IL-6 гени rs1800795 полиморфизми ва ангиогенез жараёнига алоқадор VEGF гени rs2010963 полиморфизмлари бўйича ўзида минор аллел тутган беморларда COVID-19 индуцирлаган ишемик инсулт келиб чиқиши орасида ўзаро ассосиatsiя мавжудлигини аниқлаш бўлди.
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