SPECIFIC EFFECT OF HYPERCOMOCYSTEINEMIA ON THE ORIGIN OF ISCHEMIC STROKE OF THE BRAIN
Keywords:
homocysteine, ischemic disease of the brain, stroke, hypercomocysteinemia, methionineAbstract
The article is devoted to the role of homocysteine in the human body. Amino acid homocysteine is the product of demethylation of methionine. The accumulation of homocysteine leads to the relaxation of the walls of the arteries, the appearance of local defects in the endothelium, which in turn leads to the deposition of cholesterol and calcium into the vascular wall. As a result of the disturbed metabolism of homocysteine, it damages the vascular system of the basmia, which can lead to irreversible ischemic brain damage.
References
Г.С. Рахимбаева., Ю.А. Мусаева., Ш.Р.Рахимбердиев.(2017). Пути прогнозирования ишемического инсульта и транзиторной ишемической атаки с использованием международных шкал. Журнал теоретической и клинической медицины,номер 3,130-133.
Шмелева, В.М. Роль гипергомоцистеинемии в формировании протромботических нарушений системы гемостаза: автореф. дисс. ... докт. мед. наук / В.М. Шмелева. - СПб., 2010. - 286 с.
Adams, H.P Jr. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST Trial of Org 10172 in Acute Stroke Treatment / Adams H.P. Jr. [et al.] // Dep. of neurol., Univ. of iowa. Stroke. - 1993. - Vol. 24 (1). – P 35-41.
Andersson, A. Total homocysteine in plasma or serum: methods and clinical applications / A. Andersson, R.H. Allen // Clin. Chem. 1993. - Vol. 39. - Р 1764-1779.
Bolander-Gouaille, C. Focus on Homocysteine and the Vitamins involved in its metabolism / C. Bolander-Gouaille // Springer verlag France. - 2002. - Р. 217.
Bostom, A.G. Elevated fasting total plasma homocysteine levels and cardi-ovascular disease outcomes in maintenance dialysis patients. A prospective study / A.G. Bostom [et al.] // Arterioscler. thromb. vasc. biol. - 1997. - Vol. 17. - P 2554-2558.
Boushey, C. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes / C. Bou-shey [et al.] // JAMA. - 1995. - Vol. 274. - P 1049-1057.
Brott, T. Measurements of acute cerebral infarction: a clinical examination scale / T. Brott [et al.] // Stroke. - 1989. - Vol. 20. - P 864-870.
Butz, L. Isolation of methionine by enzymatic hydrolysis / L. Butz, De Vigneaud // J. biol. chem. - 1932. - Vol. 94. - P 641-45.
Carmel, R. Folate deficiency. Homocysteine in health and disease / R. Carmel, D.W. Jacobsen [et al.] // Cambridge, UK: Cambridge university press. - 2001. - P 271-288.
Carson, N.A. Metabolic abnormalities detected in a survey of mentally back-ward individuals in Northern Ireland / N .A. Carson, W. Neill // Arch. dis. child. - 1962. - Vol. 37. - P 505-513.
Casas, J.P Homocysteine and stroke: evidence on a causal link from mendelian randomization / J.P. Casas [et al.] // Lancet. - 2005. - Vol. 365 (9455). - P. 224-232.
Bobokulov G.D. Khodjieva D.T. Ways to optimize rehabilitation activities in hemorrhagic and ischemic stroke. Web of Scientist: International Scientific Research Journal. 2021. С.132-136
Castillo Lancellotti, C. Effect of folate and related nutrients on cognitive func-tion in older people; systematic review / C. Castillo Lancellotti, J.A. Tur Mar, R. Uauy Dagach // Nutr Hosp. - 2012.Vol. 27 (1). - P 90-102.
Khodjieva D. T., Khaydarova D. K., Khaydarov N. K. New Technologies in Treatment of Patients in the Acute Period of Stroke. American Journal of Medicine and Medical Sciences.2020.С . 393-396
Khodjieva D. T., Khaydarova D. K., Khaydarov N. K. Magnetic Resonance Imaging of Cerebral Hemorrhagic Stroke. International Journal of Psychosocial Rehabilitation, Vol. 24, 2020. 434-438
Clarke, R. Hyperhomocysteinemia: an independent risk factor for vascular dis-ease / R. Clarke [et al.] // N. Engl. J. Med. - 1991.Vol. 324. - P 1149-1155.
Cronin, S. Dose-related association of MTHFR 677T allele with risk of ischemic stroke evidence from a cumulative meta-analysis / S. Cronin, K.L. Furie, PJ. Kelly // Stroke. - 2005. - Vol. 36 (7). -P1581-1587.
М.М.Асадуллаев., Г.С.Рахимбаева., Н.М.Вахабова., Ш. Жангиров.(2021). Ўткир ишемик инсульт ривожланишдаги патогенетик механизмлар. Збiрник наукових прац SCIENTIA
Н.М.Вахабова. (2021). Структура клинико-неврологических симптомов при острых мозговых инсультах у мужчин и женщин в пожилом и старческом возрасте. Журнал неврологии и нейрохирургических исследований 2(3).
Вахабова, Н. М., Азизова, Р. Б., &Абдуллаева, Н. Н. (2019). Гендерные особенности факторов риска и фоновых заболеваний при разных вариантах ишемического инсульта у лиц пожилого и старческого возраста.
