ANALYSIS OF DIFFERENTIAL CHARACTERISTICS OF CLINICAL AND FUNCTIONAL CHANGES IN THE EARLY AND PRODROMAL STAGES OF PARKINSON'S DISEASE
Keywords:
Parkinson's disease, prodromal stage, early stage, non-motor symptoms, differential diagnosis, dopaminergic neurons, neurodegeneration, biomarkers, neurovisualizationAbstract
Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by the progressive loss of dopaminergic neurons in the brain's substantia nigra. Traditionally, the diagnosis of Parkinson's disease was based on the identification of classical motor symptoms - resting tremor, rigidity, bradykinesia, and postural instability. However, modern studies show that the pathological process in PD begins long before the manifestation of motor disorders, passing through the prodromal and early stages of the disease.
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Вклад авторов
Сафаров Комилжон Камолович внеc основной вклад в разработку концепци статьи, Хайдарова Дилдора Кодировна подготовила текст, и согласен принять на себя ответственность за все аспекты клического наблюдения и участвовали в разработке концепции статьи и подготовке текста, а также принимали активное участие в лечение пациента, подготовки материалов и описании клинического наблюдения. Автором было одобрено окончательная версия публикации.
Mualliflar hissasi
Safarov Komiljon Kamolovich maqola konsepsiyasini ishlab chiqishda asosiy hissa qo‘shdi. Haydarova Dildora Qodirovna matnni tayyorladi va klinik kuzatuvning barcha jihatlari uchun javobgarlikni o‘z zimmasiga olishga rozi bo‘ldi. Ular maqola konsepsiyasini ishlab chiqish va matnni tayyorlashda ishtirok etdilar, shuningdek, bemorni davolash, materiallarni tayyorlash va klinik kuzatuvni tavsiflashda faol qatnashdilar. Muallif nashrning yakuniy nusxasini ma’qulladi.
AUTHORS CONTRIBUTIONS
Safarov Komiljon Kamolovich made the main contribution to the development of the article's concept, Haydarova Dildora Kodirovna prepared the text and agreed to take responsibility for all aspects of clinical observation and participated in the development of the article's concept and preparation of the text, as well as actively participated in patient treatment, preparation of materials, and description of clinical observation. The author approved the final version of the publication.
