INSULT VA SURUNKALI BUYRAK KASALLIGI: EPIDEMIOLOGIYA, PATOGENEZ VA BUYRAK KASALLIGI BOSQICHLARIDA DAVOLASH
##article.subject##:
: buyrak; mikrotomir kasalliklari; mikroqon ketish; hayvonlar modellari##article.abstract##
Ko'pgina tadqiqotlar surunkali buyrak kasalligi (CKD) va serebrovaskulyar kasalliklar o'rtasidagi bog'liqlik haqida xabar beradi. Bu assotsiatsiya, ayniqsa, kichik miya tomirlari kasalliklari uchun kuchli bo'lgan. Muhim topilmalar ish hisobotlari, kichik holatlar seriyasi va kattaroq kohort tekshiruvlarigacha bo'lgan tadqiqotlar natijasida paydo bo'ldi. Ikkinchisi buyrak funktsiyasining pasayishi, mikrovaskulyar kasalliklar va kognitiv buzilishlar o'rtasidagi munosabatni ko'rsatadi. Xavotirli jihatlardan biri bu CKD-miya qon tomir kasalliklari bilan bog'liqligini ko'rsatadigan mexanik tadqiqotlarning nisbatan kamligi edi. Shunga qaramay, mexanik kuzatuvlar paydo bo'la boshladi, bu klinik tadqiqotlarda muhim birgalikdagi kasallik bo'lgan gipertenziyadan mustaqil bo'lgan CKD ning hayvon modellarida miya mikroqon ketishining rivojlanishini ko'rsatadi. Dastlabki hujayra madaniyati tadqiqotlari CKD sarumi tomonidan endotelial monoqatlamning buzilishini ko'rsatadi, bu qon-miya to'sig'ining shikastlanishini ko'rsatadi.
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