ПАРАЩИТОВИДНЫЕ ЖЕЛЕЗЫ: АНАТОМО-ФИЗИОЛОГИЧЕСКИЕ АСПЕКТЫ И ДЕЙСТВИЕ ГОРМОНОВ
Ключевые слова:
Паращитовидные железы, паратгормон, кальций, фосфор, витамин D, рецептор витамина D, FGF23, FGFRs, белок КлотоАннотация
В обзорной статье авторы представили данные об анатомии и физиологии паращитовидных желез, молекулярном механизме действия паратиреоидного гормона, взаимодействии с витамином D, его производными и рецепторами, а также подробно объяснили роль кальцитонина, FGF23, FGFRs, кальций-чувствительного рецептора. CaSR и белок Klotho. Подробно с иллюстрациями описано гормональное действие ПТГ, особенно в регуляции уровня кальция и фосфора в плазме крови и в минерализации костей. Описаны данные о нарушении минерального обмена и поражении паращитовидных желез с развитием первичной, вторичной и третичной патологии. Этот обзор представляет интерес для семейных врачей, врачей-специалистов, таких как эндокринолог, нефролог, гемодиализных врачей, хирургов, а также для студентов и ординаторов.
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