ЗНАЧЕНИЕ ДЕФИЦИТА ВИТАМИНА D3 В РАЗВИТИИ ХРОНИЧЕСКИХ ОСЛОЖНЕНИЙ САХАРНОГО ДИАБЕТА
Ключевые слова:
Диабет, диабетические осложнения, дефицит витамина D3Аннотация
Актуалность: Сахарный диабет 2 типа представляет собой глобальную эпидемию, ее актуальность выражается в развитии тяжелых сосудистых осложнений, вызывающих раннюю инвалидность, а в конечном итоге вызывающих социальные и экономические проблемы. В статье рассматриваются современные представления о вкладе витамина D в патофизиологические и биохимические основы обмена глюкозы и его участии в регуляции воспалительных процессов. Доказано, что в условиях дефицита витамина D изменения активности рецепторов витамина D или изменения концентрации внеклеточного и внутриклеточного кальция отрицательно влияют на функциональное состояние β-клеток поджелудочной железы, что может привести к снижению синтеза и секреции инсулина. Также представлены современные представления о роли дефицита витамина D в развитии инсулинорезистентности. С учетом представленных в обзоре фактов высказано предположение, что дефицит витамина D можно рассматривать как неклассический фактор риска развития не только диабета, но и его осложнений.
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